Protein Details: Small conductance calcium-activated potassium channel protein 3
Protein ID
ICDB_Pro_0642
Protein Name
Small conductance calcium-activated potassium channel protein 3
Gene Name
Kcnn3; Sk3
Organism
Mus musculus (Mouse)
Length
732 amino acids
AlphaFoldDB
AF-P58391-F1-model_v4.pdb
Function
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)
Sequence
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPPAPPAVPQQPPGPLLQPQPPQPQQQQSQQQQQQQSQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPTSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTVILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed at low levels in atrial and ventricular myocytes (at protein level).
DOI ID
10.1152/ajpgi.2001.281.4.g964; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1152/ajpheart.00534.2005; 10.1016/j.cell.2010.12.001
RefSeq
NP_536714.2